jneuroJournal of Neurology and NeuropsychiatrycoVolume 2 Issue 2 (July-Dec)MultidisciplinaryEnglish6 Months NNY20251225Neurological DisorderInfectious Diseases as a Potential Risk Factor for Parkinson’s Disease and Parkinsonism: A Scoping ReviewEnglishY113Paula Abola 1*EnglishNDita Cerina2EnglishYhttps://doi.org/10.71117/JNNP.2025.2202Parkinsonism is a syndrome characterized by bradykinesia, rigidity, tremor, and postural instability, with Parkinson’s disease (PD) being the most common cause. Increasing evidence suggests that infectious diseases may play a role in triggering or exacerbating Parkinsonian symptoms through direct neurotoxicity, neuroinflammation, or alterations in the gut--brain axis. \textbf{Methods:} A scoping review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines was conducted. PubMed, Cochrane, and MEDLINE databases were searched for studies examining infections, PD, and Parkinsonism. Eligible studies assessed infection-related PD or Parkinsonism risk and symptom modulation. \textbf{Results:} Thirty-seven studies met the inclusion criteria. Several infections were linked to Parkinsonism, with chronic viral infections such as hepatitis C virus (HCV) and hepatitis B virus (HBV), and bacterial infections including \textit{Helicobacter pylori} and \textit{Clostridium difficile}, associated with an increased risk of PD, while some infections showed no significant effect. Acute infections, such as urinary tract and respiratory infections, were frequently linked to transient worsening of symptoms. Antiviral therapy and \textit{H. pylori} eradication demonstrated potential benefits, although findings were inconsistent. \textbf{Conclusion:} The relationship between infections and PD is complex, with certain infections potentially triggering or worsening symptoms, while others appear neutral or protective. Understanding infection-related mechanisms of neurodegeneration is essential for developing preventive and therapeutic strategies. Further longitudinal studies are needed to clarify causal links and optimize infection management in PD.EnglishParkinsonism, neuroinflammation, bradykinesiahttps://jneuro.clsconf.com/admin/abstract?id=37References1619Duda JE, Lee VMY, Trojanowski JQ. Degenerative Disorders. Published online 2003:825and;ndash;832. Doi: https://doi.org/10.1016/b0-12-226870-9/01063-7 [Google Scholar] [PubMed]Vertes AC, Khan Suheb MZ. Parkinson-plus Syndrome. Published online 2022. Available at: https://www.ncbi.nlm.nih.gov/books/NBK585113/ [Google Scholar]Tansey MG, Wallings RL, Houser MC, Herrick MK, Keating CE, Joers V. Inflammation and immune dysfunction in Parkinson disease. Nature Reviews Immunology 2022;22:1and;ndash;17. Doi: https://doi.org/10.1038/s41577-022-00684-6 [Google Scholar] [PubMed]Henry J, Smeyne RJ, Jang H, Miller B, Okun MS. 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